解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the brain. Glymphatic system activity increases during sleep or ketamine/xylazine (K/X) anesthesia, yet the mechanism(s) facilitating CSF in...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5447
更新日期:2019-02-27 00:00:00
abstract::The Paris Agreement aims to mitigate the potential impacts of climate change on ecological and social systems. Using an ensemble of climate-marine ecosystem and economic models, we explore the effects of implementing the Agreement on fish, fishers, and seafood consumers worldwide. We find that implementing the Agreeme...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3855
更新日期:2019-02-27 00:00:00
abstract::Species interactions have long been predicted to increase in intensity toward the tropics and low elevations because of gradients in climate, productivity, or biodiversity. Despite their importance for understanding global ecological and evolutionary processes, plant-animal interaction gradients are particularly diffi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau4403
更新日期:2019-02-20 00:00:00
abstract::Recently, the complexity behind manipulations of reflected fields by metasurfaces has been addressed, showing that, even in the simplest scenarios, nonlocal response and excitation of auxiliary evanescent fields are required for perfect field control. In this work, we introduce purely local reflective metasurfaces for...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7288
更新日期:2019-02-15 00:00:00
abstract::Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0450
更新日期:2019-02-13 00:00:00
abstract::Many animals understand numbers at a basic level for use in essential tasks such as foraging, shoaling, and resource management. However, complex arithmetic operations, such as addition and subtraction, using symbols and/or labeling have only been demonstrated in a limited number of nonhuman vertebrates. We show that ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav0961
更新日期:2019-02-06 00:00:00
abstract::Understanding how surfaces direct nucleation is a complex problem that limits our ability to predict and control crystal formation. We here address this challenge using high-speed imaging to identify and quantify the sites at which ice nucleates in water droplets on the two natural cleavage faces of macroscopic feldsp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav4316
更新日期:2019-02-01 00:00:00
abstract::V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domai...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8149
更新日期:2019-01-30 00:00:00
abstract::Biogenesis in prokaryotes and eukaryotes requires the insertion of α-helical proteins into cellular membranes for which they use universally conserved cellular machineries. In bacterial inner membranes, insertion is facilitated by YidC insertase and SecYEG translocon working individually or cooperatively. How insertas...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau6824
更新日期:2019-01-30 00:00:00
abstract::The discovery of high-temperature superconductivity in cuprates ranks among the major scientific milestones of the past half century, yet pivotal questions regarding the complex phase diagram of these materials remain unanswered. Generally thought of as doped charge-transfer insulators, these complex oxides exhibit ps...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau4538
更新日期:2019-01-25 00:00:00
abstract::Mesoscale turbulence in the ocean strongly affects the circulation, water mass formation, and transport of tracers. Little is known, however, about how mixing varies on climate timescales. We present the first time-resolved global dataset of lateral mesoscale eddy diffusivities at the ocean surface, obtained by applyi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5014
更新日期:2019-01-23 00:00:00
abstract::The prominent size effect of metal nanoparticles shapes decisively nanocatalysis, but entanglement of the corresponding geometric and electronic effects prevents exploiting their distinct functionalities. In this work, we demonstrate that in palladium (Pd)-catalyzed aerobic oxidation of benzyl alcohol, the geometric a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat6413
更新日期:2019-01-18 00:00:00
abstract::Reef-building corals form their calcium carbonate skeletons within an extracellular calcifying medium (ECM). Despite the critical role of the ECM in coral calcification, ECM carbonate chemistry is poorly constrained in vivo, and full ECM carbonate chemistry has never been characterized based solely on direct in vivo m...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7447
更新日期:2019-01-16 00:00:00
abstract::A rapid, direct, and low-cost method for detecting bacterial toxins associated with common gastrointestinal diseases remains a great challenge despite numerous studies and clinical assays. Motion-based detection through tracking the emerging micro- and nanorobots has shown great potential in chemo- and biosensing due ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9650
更新日期:2019-01-11 00:00:00
abstract::In retinal detachment (RD), photoreceptor death and permanent vision loss are caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9940
更新日期:2019-01-09 00:00:00
abstract::Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibil...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat2953
更新日期:2019-01-09 00:00:00
abstract::Animal collective motion arises from the intricate interactions between the natural variability among individuals, and the homogenizing effect of the group, working to generate synchronization and maintain coherence. Here, these interactions were studied using marching locust nymphs under controlled laboratory setting...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav0695
更新日期:2019-01-02 00:00:00
abstract::Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau2956
更新日期:2019-01-02 00:00:00
abstract::The control of product distribution in a multistep catalytic selective hydrogenation reaction is challenging. For instance, the deep hydrogenation of dimethyl oxalate (DMO) is inclined to proceed over Cu/SiO2 catalysts because of inevitable coexistence of Cu+ and Cu0, leading to hard acquisition of the preliminary hyd...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3275
更新日期:2018-12-21 00:00:00
abstract::After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau5064
更新日期:2018-12-19 00:00:00
abstract::Carbon deposits are well-known inhibitors of transition metal catalysts. In contrast to this undesirable behavior, here we show that epitaxial graphene grown on Ru(0001) promotes the reversible formation of a C-C bond between -CH2CN and 7,7,8,8-tetracyano-p-quinodimethane (TCNQ). The catalytic role of graphene is mult...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9366
更新日期:2018-12-14 00:00:00
abstract::We analyze a collection of empirical networks in a wide spectrum of disciplines and show that strong non-normality is ubiquitous in network science. Dynamical processes evolving on non-normal networks exhibit a peculiar behavior, as initial small disturbances may undergo a transient phase and be strongly amplified in ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9403
更新日期:2018-12-12 00:00:00
abstract::Amorphous solids, such as glasses, have complex responses to deformations, with substantial consequences in material design and applications. In this respect, two intertwined aspects are important: stability and reversibility. It is crucial to understand, on the one hand, how a glass may become unstable due to increas...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat6387
更新日期:2018-12-07 00:00:00
abstract::We present a framework for quantifying the spatial and temporal co-occurrence of climate stresses in a nonstationary climate. We find that, globally, anthropogenic climate forcing has doubled the joint probability of years that are both warm and dry in the same location (relative to the 1961-1990 baseline). In additio...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3487
更新日期:2018-11-28 00:00:00
abstract::Demonstration of ultralow energy switching mechanisms is imperative for continued improvements in computing devices. Ferroelectric (FE) and multiferroic (MF) order and their manipulation promise an ideal combination of state variables to reach attojoule range for logic and memory (i.e., ~30× lower switching energy tha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat4229
更新日期:2018-11-23 00:00:00
abstract::A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8408
更新日期:2018-11-21 00:00:00
abstract::The structural hierarchy exhibited by materials on more than one length scale can play a major part in determining bulk material properties. Understanding the hierarchical structure can lead to new materials with physical properties tailored for specific applications. We have used a combined experimental and phase-fie...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao6051
更新日期:2018-11-16 00:00:00
abstract::Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9859
更新日期:2018-11-14 00:00:00
abstract::The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau6986
更新日期:2018-11-07 00:00:00
abstract::Slow slip events have been suggested to trigger subduction earthquakes. However, examples to date have been poorly recorded, occurring offshore, where data are sparse. Better understanding of slow slip events and their influence on subsequent earthquakes is critical for hazard forecasts. We analyze a well-recorded eve...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat8472
更新日期:2018-10-31 00:00:00
abstract::The key component currently missing for the next generation of transparent and flexible displays is a high-performance polymer material that is flexible, while showing optical and thermal properties of glass. It must be transparent to visible light and show a low coefficient of thermal expansion (CTE). While specialty...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau1956
更新日期:2018-10-26 00:00:00
abstract::Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3075
更新日期:2018-10-24 00:00:00
abstract::Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell to polarize in the left-right axis. Despite increasing evidence on its substantial role in the asymmetric development of embryos, little is known about implications of cell chirality in physiology and disease. We demon...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat2111
更新日期:2018-10-24 00:00:00
abstract::Quantum teleportation, which is the transfer of an unknown quantum state from one station to another over a certain distance with the help of nonlocal entanglement shared by a sender and a receiver, has been widely used as a fundamental element in quantum communication and quantum computation. Optical fibers are cruci...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9401
更新日期:2018-10-19 00:00:00
abstract::Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunct...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau1780
更新日期:2018-10-17 00:00:00
abstract::Active materials are capable of converting free energy into directional motion, giving rise to notable dynamical phenomena. Developing a general understanding of their structure in relation to the underlying nonequilibrium physics would provide a route toward control of their dynamic behavior and pave the way for pote...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat7779
更新日期:2018-10-12 00:00:00
abstract::Exploration for superconductivity is one of the research frontiers in condensed matter physics. In strongly correlated electron systems, the emergence of superconductivity is often inhibited by the formation of a thermodynamically more stable magnetic/charge order. Thus, to develop the superconductivity as the thermod...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3489
更新日期:2018-10-05 00:00:00
abstract::Measuring motor skill proficiency is critical for the certification of highly skilled individuals in numerous fields. However, conventional measures use subjective metrics that often cannot distinguish between expertise levels. We present an advanced optical neuroimaging methodology that can objectively and successful...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat3807
更新日期:2018-10-03 00:00:00
abstract::Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat9660
更新日期:2018-09-26 00:00:00
abstract::Dirac materials such as graphene and topological insulators (TIs) are known to have unique electronic and spintronic properties. We combine graphene with TIs in van der Waals heterostructures to demonstrate the emergence of a strong proximity-induced spin-orbit coupling in graphene. By performing spin transport and pr...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat9349
更新日期:2018-09-21 00:00:00